Hypertrophic cardiomyopathy (HCM) remains a significant cause of morbidity and mortality in pediatric patients, with cardiac death being a particularly devastating outcome. This study presents a systematic synthesis of risk factors associated with cardiac mortality in pediatric HCM patients using a meta-analysis approach. Our comprehensive meta-analysis involved an extensive search of the existing literature, resulting in the inclusion of multiple studies and datasets that collectively encompassed a substantial cohort of pediatric HCM cases. The primary objective was to identify and quantify the risk factors that significantly contribute to cardiac mortality in this vulnerable population. Our findings reveal several critical risk factors associated with an increased likelihood of cardiac mortality in pediatric HCM, including genetic mutations, severity of left ventricular hypertrophy, the presence of arrhythmias, and the degree of family history involvement. Through a rigorous statistical analysis, we have established the strength of these associations and their relative impact on the risk of cardiac death. Furthermore, this meta-analysis offers insights into the potential role of therapeutic interventions and their impact on reducing cardiac mortality in pediatric HCM patients. By integrating data from various sources, we have provided a robust overview of the current state of knowledge regarding the risk factors for cardiac mortality in this population.